Sherlock Holmes gets in trouble with his landlady Mrs. Hudson for not paying his rent. Holmes’ friend, Dr. Stamford, suggests Holmes get a flatmate and sends Dr. John Watson, whom Holmes deduces is a retired army doctor. Mrs. Hudson is impressed enough to allow Watson to become Holmes’ flatmate. Inspector Lestrade of Scotland Yard arrives and arrests Holmes for suspicion of murdering Count Drebber.

With 48 minutes remaining before the train reaches the next station, Sherlock declares that William and he can find the murderer in time. Sherlock relies on the evidence at the scene, while William pursues a psychological profile of the killer.