After fleeing a police roadblock where he gets shot in the leg, Kimble hops on a truck headed toward Sacramento where he meets Sister Veronica (the nun whom he drove from Nevada to Sacramento in the 'Angels Travel on Lonely Roads' episodes) whom is now the principal of the St. Mary Magdalene School for girls. Kimble asks Sister Veronica to drive him to Tarlton, where the one-armed man supposedly works as a numbers runner for a local racketeer. But a 'bad-girl' student recognizes Kimble and calls the police, forcing Kimble to hide on the roof of a building despite his injury. Meanwhile, Sister Veronica (whom is suffering from a brain tumor) learns that another delinquent student has run away, and is torn between driving after the girl or staying to help Kimble.

While attending a minor league baseball game, Kimble unwittingly witnesses a man walk away with a woman whom is later revealed to be the daughter of newspaper publisher Andy Newark. After discovering that Kimble witnessed the proceedings, Newmark summons Kimble to his office where he tells him that the woman is his daughter and she has been kidnapped. Her abductors want a $200,000 ransom. When word leaks out, reporters surround the Newmark household and Kimble is unable to slip away. Meanwhile, the kidnappers, a former baseball player and a friend, realize that Kimble witnessed them. So, they plot to have Kimble deliver the ransom money so they can kill him.

Fritz Simmons is a college professor doing research on sleep depervation. One of his patients is the one-armed man Fred Johnson, whom works as a groundskeeper at Wellington College. When Johnson begins talking in his sleep about having killed a woman, Fritz contacts Kimble. When Kimble arrives, he verifies that it is indeed Johnson, and he and Fritz realize that by recording Johnson's confession will prove Kimble's innocence. Meanwhile, Gerard has found out about the experiments from Fritz's wife Caroline, and believes that Kimble may be on the premises. Gerard's arrival at the facility leads to an incredible confrontation between himself, Kimble and the one-armed man.

Fleeing to Mexico, Kimble somehow contracts pnenmonia and seeks refuge at a local hospital where he is recognized by Dr. Howell, an ambitious American doctor whom is conducting reseach on menigitis. After Kimble recovers, Dr. Howell blackmails him into assisting with his research in exchange for protection from the local state police. While working with Howell's assistant, the attractive Reina Morales, Kimble soon discovers that several of the patients are being unwittingly infected and sacrificed for Howell's research purposes. Meanwhile, a persistent police sergeant, named Rodriguez, begins investigating Kimble's true idenity.

Kimble, working as a truck driver out of Portland, Oregon, becomes romantically involved with the radio dispatcher Barbara Wells, unaware that she is a convicted embezzler on loan through the state prison's work-release program. Distraught after her parole is denied for another six months, Barbara flees to Seattle where Kimble is staying and asks to take her to Canada with him. But when Kimble learns the truth, he decides to take her back to Seattle. Meanwhile, Barbara's parole officer, Art Meredith, soon stumbles upon Kimble's true idenity and decides to set a trap for him to bring both Kimble and Barbara back to Portland.