In San Francisco, Kimble is nearly run over by a car driven by Ruth Norton, a young flight attendent distraught over discovering that the man she has been dating for the past four months is married with two children. While recuperating in the hospital, a delirious Kimble flashes back to the months leading upto the night of Helen Kimble's murder and Kimble first seeing the one-armed man fleeing from his house. Followed by Kimble's trial, sentence, and escape from the train wreck. Ruth, who has been keeping a vigil at Kimble's bedside, hears him mutter Helen's name. Thinking that he's in some kind of trouble, Ruth takes Kimble (now going by the alias George Browning) to her apartment to recover. Kimble then gives Ruth advice on her relationship with her boyfriend, Paul, and to put her life problems in perspective.

Beliving that the one-armed man is in Chicago, Kimble contacts Mike Decker, a newspaper columnist who defended Kimble during his trial. Kimble and Decker organize a city-wide search for the one-armed man. But things get complicated with the arrival of Decker's alcholic wife, Paula, whom gets nervous of Kimble's presence and falls off the wagon. Meanwhile, Gerard learns about Decker's search for a one-armed man and decides to use the writer to set a trap for Kimble.