After a new memory, Andrea finds it hard to believe what his memory seems to be suggesting to him, and he asks Enrico to discontinue treatment. Even on the ward, the situation is far from quiet. In addition to Rita, a young girl who refuses chemotherapy, Andrea and his team have to deal with the case of a patient they know all too well.

Doc sees some of the certainties he had about his past collapsing and, to shed light on what happened, he also drags Giulia into his search, who is challenged by the idea that her relationship with Andrea was based on a lie. Angelo, a patient whose condition forces Martina to prove herself, has problems with his past, too.

The therapy sessions with Enrico seem to have side effects on Doc, who sees his ability to take care of patients called into question. Agnese seizes the opportunity to crush his research into the past, while Giulia is convinced that Andrea should not give up, despite his problems: in fact, his brother Fabio is admitted to the ward.

Doc finally knows how to track down the woman he is looking for, but he must first find the courage to do so. Meanwhile, Ric faces the case of an undisciplined personal trainer, while Damiano must deal with the hospitalization of a model, his brother Samuele's girlfriend. This case threatens to bring up old family grudges.

Doc enters a competition with an AI: if he does not want to be replaced by a machine, he must find the correct diagnosis for a patient before the computer. Martina, on the other hand, is given a case that forces her to come to terms with her conscience, while Agnese is confronted with a terrible decision to protect one of Andrea's secrets.

Agnese's words have created a rift with Andrea, who must also come to terms with being away from Giulia, who is in Rome for research. Meanwhile, Teresa must work wonders to find a place for Diana's daughter, admitted despite her mother's doubts. Elisabetta is also admitted to the ward after a few days of illness, maybe an indication of a more serious problem.

The deadline to submit the research is approaching, but Giulia seems to have other things on her mind. Even Doc struggles to manage the myriad commitments: there's the meeting with the funders and then there's Carolina, who is in town for a few days. Everything takes a back seat, however, when Lin's sister is hospitalized. A case that will force the resident to come to terms with her father.

Giulia must make a decision about her personal life that will also affect her career. While Martina faces the most difficult exam of her life, Ric takes on a case that will force him to come to terms with Alba's ghost. Lin and Federico, on the other hand, get back to work on the database, but they risk bringing Doc closer to the truth that Agnese has been hiding from him.