In this second episode to feature Meena Calhoun and her father, Hoss and Joe's plans to sell horses from the livery stables in town is thwarted. Virgil and his two brothers also go into the livery business which creates troubles for Hoss and Joe.

Dusty takes in orphaned Jamie Hunter, the son of a recently-deceased rainmaker. Jamie is determined to carry on his father's tradition by using drought-stricken Virginia City to prove his talents.

A man called Davis has shot Colonel Clayton and escapes on horseback. Joe and Ben join the posse that sets out to find Davis. Ben and Joe volunteer to cross the desert. Ben and Joe find Davis hold up at a water hole, when Indians attack and Ben is wounded in the leg, and steal the horses. Joe unties Davis, who tends to a wounded Ben, who is suspicious that Davis will try to escape. After playing a game of cat and mouse, Ben and Davis come to an agreement: survival. Joe makes the decision to cross the desert on foot, while Ben and Davis are at the water hole, both men in need of medical help and justice.

An insecure Jamie is unsure of his place in the family, having trouble adjusting at his new school and keeps getting harassed by a bully. When he takes Ben's prized gold-plated rifle and breaks it, he runs away, sending Ben to go looking for him.

Neta, a teen-age girl who is a friend of Jamie's, witnesses an assault and robbery. The victim - Mr. Trumbull, a man who is about to inherit a fortune - dies. The culprit, a drifter named Griff Bannon, gets a glimpse of Neta and, after fleeing the scene, plots to assume his victim's identity and stalk the witness. Her father, meanwhile, is no help, since he raises her by ""traditional values"" and forbids her to socialize with the Cartwrights. Meanwhile, the imposter - now working for the Cartwrights - begins to track Neta's every move and plans to seal her silence, unless she can summon the courage to tell Jamie and the others about the crime she witnessed and identify the baddie.

When Luke Calhoun loses all his money in a stock scheme, he and his daughter Meena stay at the Ponderosa with disruptive consequences. Luke turns the ranch into a casino and Meena continues her frantic search for a husband, where she left off in season eleven's "Meena".