A priest is brutally killed, and a young member of his congregation is the prime suspect. Despite the boy's affirmations of guilt, Sara suspects something else is at work. Investigating, she comes to believe that the boy was possessed by demons, and yet she still believes he was not the one responsible. She also fences with Father Del Toro, who has been assigned by the Vatican to investigate. Del Toro seems to know a great deal about the Witchblade as well, from its time when it was kept at the Vatican. Eventually Del Toro is revealed as the true murderer.

A killer known only as V tries to take over New York's organized crime syndicates, causing mayhem. But when the evidence gathered at the crime scenes includes the fingerprints of Sara's long-dead father, Sara must trust the Witchblade's powers to overcome her emotions and wage war with the greatest evil she has ever faced.