A year after rescuing Catherine Martin from the horror of Buffalo Bill’s basement, FBI Agent Clarice Starling gets an urgent assignment from Catherine’s mother, Attorney General Ruth Martin, to join the Violent Criminal Apprehension Program (VICAP) in the investigation of three serial killings.

On the heels of ViCAP uncovering the secrets behind the River Murders case, Clarice is imprisoned in an abandoned animal testing facility where she finds trafficked women being held captive. As Clarice attempts to break from her captors and rescue all the women, ViCAP and Ardelia team up to locate her.