The U.S.S. Enterprise encounters a contagion that ravages the ship. One by one, the entire crew is incapacitated except for Number One, Una Chin-Riley, who must now confront a secret she’s been hiding as she races to find a cure.

A threat to an idyllic planet reunites Captain Pike with the lost love of his life. To protect her and a scientific holy child from a conspiracy, Pike offers his help and is forced to face unresolved feelings of his past.

The U.S.S. Enterprise becomes stuck in a nebula that is home to an alien consciousness that traps the crew in a fairy tale.