This episode features Seth Rogen (Steve Jobs) with Jennifer Jason Leigh (The Hateful Eight), Amy Schumer (Trainwreck) with Lily Tomlin (Grandma), Joseph Gordon-Levitt (The Walk) with Paul Dano (Love & Mercy), and Isabella Rossellini (Joy) with Charlotte Rampling (45 Years).

Viola Davis ("The First Lady") and Samuel L. Jackson ("The Last Days of Ptolemy Grey") share their advice for young actors; Jennifer Aniston ("The Morning Show") and Sebastian Stan ("Pam & Tommy") reveal how they spend their time in the makeup chair; and Jared Leto ("WeCrashed") and Amanda Seyfried ("The Dropout") discuss their responsibility in playing real people.