Struggling hairdresser and single mother Jolene tries to convince lonely housewife Miranda to go with her on a girls weekend - with diapers. When Miranda finds herself in a violent confrontation with her slimy husband Blair, the girls weekend and possibility of escape suddenly seems like the very best plan.

On their girls' weekend in Florida, Miranda and Jolene have a chance meeting with party girl Samantha, who introduces them to queenpin Xorge and her beauty/wellness empire Bae Mine Beauty. Fast forward to one year later in small town Pictonville: the women are running the Bae Mine Beauty Pictonville branch, Nick and Jolene are back together raising Violet and Miranda and Rosa's newfound relationship is showing some growing pains under the roof of Rosa's uber-religious mother.

Miranda and Jolene start to question the Bae Mine Beauty products they've been successfully selling when courier Bob's nosiness raises a red flag. Fledgling psychic Frankie joins a hospital reading program only to find herself reading to ex-criminal Stella, who is still in a coma after a year.

Stella wakes up from her coma and word spreads through the Pictonville community. Xorge hears the news in Florida and tells Samantha they're taking a trip up to the small town. Jolene and Miranda's new Bae Mine Beauty pills ("relaxants") prove to be wildly popular, but when one of their customers dies, the two are forced to come to terms with what they're really selling.

Jolene and Miranda debate the ethics of what they're doing. Xorge pays her sister-the newly awakened Stella-a visit and asks about a long-lost ring. Cop duo Nick and Rosa start investigating the town's recent overdose.

When Miranda ruins their current supply of "relaxants," the women manufacture a crafty solution by making fake glue pills. Xorge pieces together Jolene and Miranda's deceptions and decides to send them a forceful message.

Miranda prepares to pay back her debts to Xorge with the fortune she has been storing away, creating friction between her and Jolene. Health inspector Carl shows up at Jolene's salon at an inopportune moment.

With Violet's birthday party in full swing, Xorge shows up to collect her debt. After spending some time together, Miranda opens up to the kidnapped Carl. Xorge gets way too cozy with Violet, pushing Jolene over the edge.

Jolene and Miranda frantically try to get rid of the body as Carl talks with the police. They make a pit stop at the hospital to capitalize on Frankie's newfound psychic abilities.

Nick is forced to decide between family duty and cop duty. Back at her house, Xorge surprises Jolene and Miranda, leading to a violent altercation. Rosa is confronted by her mom about her relationship with Miranda.

While interrogating Carl, Rosa finally pieces together what Miranda's been up to. Jolene and Miranda crash a Bae Mine Beauty sales party to reveal the truth about the substances they've been peddling.

Stella offers a deal to release the women from their business commitments with Xorge. After Nick shows up, the standoff is resolved and the women make frantic plans to leave behind their old lives.