West witnesses eerie phenomena when he takes refuge with a sheriff and his prisoner in an abandoned bayou mansion.

The agents travel to Hayes City to identify the body of their archnemesis, Dr.Loveless. While there, they meet up with Miguelito's next of kin, Dr.Liebknicht, a Swiss neurologist. However, as they pursue the origin of a key found on the body, they find that Loveless is hardly dead and has plans to use his neurologist guise to give Jim a lobotomy!

On a dusty Californian trail,Jim and Artemus intercept a stagecoach whose driver has been hired to smuggle boll weevils. Quickly theorizing that someone is trying to destroy the country's cotton crop,they set out to find the mastermind of the operation and destroy his distribution system before his plan succeeds.