Doctor Finnix begins to taper Betsy off OxyContin, Bridget sees the toll the drug is taking on communities, Rick and Randy investigate the world of “pain societies”, and with sales climbing, Richard Sackler makes bigger plans for his new drug.

Richard Sackler and Purdue work the system to prevent their drug from being reigned in, Bridget has a breakthrough in her mission, Betsy has hit rock-bottom while Finnix explores new avenues, and Rick and Randy ready their criminal case.