Rebel stops at nothing to convince Cruz to join her fight against Stonemore Medical and simultaneously enlists Lana and Cassidy to protect a woman from her abusive boyfriend. While Rebel is out saving others, her husband, Grady, stands on the sidelines and picks up the pieces at home.

Rebel and a group of residents take a stand to fight for clean water. Meanwhile, Cassidy’s new role puts the Stonemore case in jeopardy, and Grady grows frustrated when Rebel remains consumed with her work, and Cruz reaches his breaking point.

Rebel goes to great lengths to help save Helen's life after being denied her surgery and continues to push Cruz to negotiate the recall and study of the heart valve. Meanwhile, Cassidy and Lana try to help Luke when his personal life jeopardizes his career and reputation. Elsewhere, Cruz gets close to someone new.

While Rebel tries to convince a key witness to testify in their case against Stonemore Medical, Lana confronts Grady about someone from his past.