Wes' former colleague, U.S.-based agent Tyler Booth, enlists the Fly Team's assistance in helping him capture an American on the FBI's "Most Wanted" list by luring him out of Russia with the help of the perp's conflicted ex-wife.

When a Russian biochemist is assassinated for trying to defect with his highly sensitive biotoxins research, the Fly Team springs into action to protect his daughter, whose father’s last wish was that she get his research to a trusted American microbiologist. Meanwhile, Mitchell stays behind to help Vo during her recovery, and Booth clashes with Smitty when he finds out she could jeopardize his promotion.