Duckman is cast in a hospital educational film with Joe Walsh; for his part he is put into a MRI chamber. The film crew is thrown out of the lab and Duckman forgotten. Left too long in the chamber, a mutation occurs which a doctor identifies as a cure for cancer. Now everyone wants Duckman's brain for their own purposes. Meanwhile, Agnes is still impersonating Grandma-ma.

Duckman plans a big poker for the evening. Unfortunately before the game his obnoxious Uncle Mo arrives and claims he is dying. To avoid the curse that befell his cousin, Duckman tries to wait on him hand and foot. Just how much of his Uncle can he take?