Captain America, Shanna the She-Devil, Namor the Sub-Mariner, Dr. Strange, and the Spider Friends face off against The Chameleon on Wolf Island.

When unfortunate accidents stop movie-maker Sam Blockbuster from completing his Spider-Man movie, Mysterio is revealed as the source of all the previous mishaps during shooting. Mysterio blackmails Blockbuster into hiring the real Spider-Man to star in his own movie.

Dr. Faustus and The Kingpin use "Psycho-Disks" in order to mind control Captain America and Iceman into doing the Kingpin's bidding.

When Spider-Man is trying out the X-Men's Danger Room, things start to go wrong when a strange intruder named Cyberiad shows up. It turns out that he is Firestar's former boyfriend and he blames her for his current state. Since Cyberiad has control of the X-Men's mansion, can the X-Men succeed in defeating him?