In an attempt to honor Lisa's last wishes, Nate finds himself at odds with her family. Meanwhile, David and Keith look for 'genuinely new' ways to start over; Federico seeks out a priest for absolution; Vanessa gets tired of Angelica; Brenda does 'the neighbor thing' with Joe; and Ruth sings the praises of her new husband George.

David's ex-fiancee re-enters his life in search of answers to the question, 'Why me?' Meanwhile, Nate has a psychic rendezvous, Keith's new job sends him into the closet, Federico identifies with David's past, Claire decides not to let life pass her by, George dumps some surprise baggage on Ruth, and Margaret weighs in on daughter Brenda's new relationship.

Nate gives Maya 'one last look' at a memorial for Lisa, where some surprise discoveries ensue. David and Keith are inspired by a same-sex wedding; George agrees to Ruth's marriage stipulations; Federico is disturbed by the 'new and improved' Vanessa; Brenda crosses a bridge with her therapy client; and Claire and Billy develop something in the darkroom.

Ruth is giddy about going to a tantric workshop with George, who retreats to the family's emergency shelter. Meanwhile, David's last bite at a sushi restaurant threatens to cost him--and Keith--a lot more than the bill; Nate drops a bomb on Barb, which sparks a counterattack; Claire fights Russell over credit for her latest photos; Margaret's hospital stay helps Brenda and Billy begin to heal their rift; and Vanessa shows she can beat Federico at his own game.

Ruth is delighted to meet George's daughter, but worries as his paranoid 'views' of the future escalate. 'Star' Claire gets high off her newfound fame; Federico pleads his case to Vanessa, who delivers a verdict; David confronts a demon face-to-face; Keith considers a business proposal; and Nate comes to final blows with Barb and Hoyt.

Ruth dreads George's return from the hospital in light of his recent diagnosis; Nate and Brenda prep for a big day, but an emergency makes them reconsider; David and Keith discuss alternative parenting options; Rico tries internet dating; and Claire enjoys domestic bliss but crosses a line with her camera.