Dr. Helen Magnus, her daughter Ashley, and new to the Sanctuary, Dr. Will Zimmerman release three women from a mysterious crypt in Scotland, bringing them back to the Sanctuary for refuge. Unbeknown to the team, and the women themselves, they have extraordinary powers. And their disappearance does not go undetected by a powerful cabal, resolute on reclaiming what it determines is theirs.

While leading a covert meeting in Rome, Magnus encounters an old friend from her past who confides that the cabal has come to exact revenge on her for the events in "Fata Morgana."