On a frozen planet, the Alphans encounter shipwrecked humans from a lost expedition. The expatriates from Earth enjoy an idyllic existence: they have been made immortal and have lived there for over 880 years. They invite the Alphans to join them in paradise, but dissidents reveal all is not at it seems, teaching Koenig that immortality comes with a price.

The automated Earth space probe Voyager One is approaching the Moon. With the radioactive exhaust from its engine certain to extinguish all life on Moonbase, the Alphans try to gain control and shut down the drive. Help comes when the probe's designer is found living on Alpha under an assumed name. However, Voyager is being followed by alien ships seeking revenge.

The Alphans celebrate the arrival of the first child born on the Moon. The blessed event sours when the infant grows into a five-year-old child in minutes. Trying to accept him, the Alphans do not notice that little Jackie Crawford is much more than he seems. When hostile spaceships approach the base, Koenig realises, too late, that the aliens have an agent on Alpha.

Encountering a derelict spaceship, the Alphans respond to an automated distress signal. On board, they discover what remains of the once-great civilisation of Daria: an elite group which maintains control of the ship and a tribe which has descended into savagery. The Alphans are appalled when they discover what measures the Darians have taken to survive.

Strange events befuddle the Alphans as they approach the planet Piri. When exploring its lifeless surface, Koenig encounters the seductive servant of the mysterious Guardian of Piri. She offers the wayward Alphans a life of peace and perfection. Realising the deadly truth behind the peace of Piri, Koenig struggles to free his people from the Guardian's influence.

While exploring an asteroid, the Alphans injure an alien trapped within. Bringing him to Alpha, they discover his wounds have completely healed. The indestructible Balor is a scientist whose people had discovered the secret of immortality. Balor is a psychopath, offering a drastic solution to his people's apathy; now freed of the eternal prison, he plans to spend eternity practicing the art of pain and torture, with the Alphans as his subjects.

A lush Earth-type planet holds the promise of a new home for the people of Moonbase Alpha. When the reconnaissance Eagle returns, it carries an unexpected passenger: Helena's husband, who died five years ago. The mysterious Lee Russell tells the Alphans that death awaits them on the new planet. The Alphans ignore his warning and unknowingly descend into a world of antimatter.

After an encounter with a space-time anomaly, the Alphans find their Moon back in the Solar System on a course to re-enter Earth orbit. The celebration ends when it becomes apparent Earth is an inhospitable wasteland. The mystery deepens when they discover a duplicate Moon already in orbit and a duplicate Moonbase Alpha lying empty and deserted.

A technician falls under an alien influence, accessing classified information before mysteriously dying. Soon after, the Moon is stopped in space by the powerful rays of an alien spacecraft. The aliens' only interest in Alpha is the data held in its computers, information they now plan to obtain through the possessed eyes of their next agent: Helena Russell.

An Eagle and its crew are crushed to death by an enormous energy field in space. When one of Alpha's astronauts is possessed by the anomaly, he tells them the energy field is a living space brain, which responded to the 'threat' with antibodies Finding the Moon on a collision course with the Brain, the Alphans make plans to avoid the same fate as the Eagle.

The wandering Moon suddenly changes course and comes to a halt in the vicinity of a dead world. As Alpha's power fails, the only hope for survival is to evacuate to the planet, which was ravaged by a nuclear war in the distant past. Searching for answers, a team is sent to the surface, where they discover the shocking truth of the origin of Mankind.

The Moon approaches a solar system with two planets on opposites sides of its sun. The Alphans are trapped in an interplanetary conflict when warships from both worlds trespass on the Moon to fire missiles at their opponents' planets. After taking in a refugee from a destroyed gunship, the Alphans discover they have drifted into the middle of a literal war of the sexes.