After ten years away, Mark Kane and his daughter, Eleanor, return home to New York City, hoping to find a cure for a rare affliction. Meanwhile their neighbor Naomi Cole, an NYPD Homicide Detective, tries to balance investigating a brutal murder at work with raising her son Isaiah, whose newly sober father has suddenly come back into their lives. Claire Logan, a brilliant scientist, receives a devastating call from her estranged father, summoning her home.

Mark and Zeke celebrate the restaurant's tenth anniversary and it ends with an unexpected bang. Meanwhile, Eleanor and Isaiah sneak out for a night of magic, wonder, and danger. Naomi struggles with new developments in her case while Claire makes great strides.