The side effects of chemo begin to plague Walt. Meanwhile, the DEA rounds up suspected dealers.

Walt faces a new threat, on a new front and deals with an increasingly angry Skyler, who must consider what to do next with her life and the kids. Meanwhile, Jesse comes face-to-face with some startling self-revelations.

Walt ignores Skyler's demands, furthering the rift between them and pushing her to break bad. Still suffering from panic and anxiety attacks, Hank crosses a line at work.

Gus increases his efforts to lure Walt back into business, forcing a rift between Walt and Jesse. Skyler doubts her new relationship. Marie confides in Skyler about her concern for Hank's well-being.

Hank's increasing volatility forces a confrontation with Jesse and trouble at work. Skyler pressures Walt to make a deal. Gus' actions have severe consequences.

As Hank's hospital bills stack up, Skyler hatches a plan. Walt and Gus come to a better understanding. Jesse, looking for more independence, pursues a new opportunity.

Skyler gets involved with Walt's business. Hank struggles with his recovery. Jesse makes a startling discovery after meeting a girl at group therapy.

With Jesse on the run and Mike in hot pursuit, Walt negotiates a bargain with Gus and concocts a disturbing plan to provide for his and Jesse's safety.

Walt and Jesse face the deadly consequences of their actions. Skyler deals with a puzzling disappearance, as Marie struggles to help Hank with his recovery.

Events spiral out of control at Jesse's place. Skyler reluctantly asks for Saul's help. Marie returns to an old pastime and a friend asks Hank for help.

When Jesse goes missing, Walt fears the worst. Skyler has an unlikely reunion. Hank shares some bad news with Detective Tim Roberts.

A frustrated Walt gambles on a risky new plan. Skyler's business venture hits a snag. Hank recruits Walter, Jr. for an unusual outing.

Skyler's past mistakes come back to haunt her. Gus takes action to thwart his rivals. Jesse seeks Walt's help, with mixed results.

Walt takes drastic action to protect his secret and Gus. Skyler's efforts to solve Ted's financial problems hit a wall.

Walt and Jesse team up to take on Gus. With Saul's help, Walt finds an unexpected ally.

As Walt deals with the aftermath of the Casa Tranquila explosion, Hank works to wrap up his investigation of Gus' empire.