While on a mission to learn more about the secrets of the mysterious writing, Coulson finds himself attacked by the only person he can trust: Agent Melinda May. Meanwhile, the rest of the team is trapped in an explosive situation, and it's up to Fitz to save them--but is he up to it?

Cal seeks revenge on Coulson by assembling a team of Super Villains to destroy S.H.I.E.L.D. Meanwhile, May calls on renowned Dr. Andrew Garner, her charismatic ex-husband, with a crisis that threatens to tear the team apart.

Gonzales and Coulson must find a way to put their differences aside and work together against HYDRA, even if it means teaming up with someone they don't trust.

Fitz and the team enlist the aid of an Asgardian to unlock the secrets of the ancient Monolith that swallowed Simmons, and Agent May is at a crossroads in her personal and professional life.

When Daisy gets a horrifying glimpse of the future, S.H.I.E.L.D. races to prove that fate is not fixed.

As Hive prepares to convert the world into his personal army, S.H.I.E.L.D. scrambles to mount a counteroffensive. Who's going to pay the ultimate price to ensure that the mission is a success?

S.H.I.E.L.D. and Ghost Rider find themselves unlikely allies when the lives of all of Los Angeles hang in the balance.

Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.

In the milestone 100th episode, Coulson finally reveals the mysterious deal he made with Ghost Rider, which will impact everyone on the team.

Coulson and the team find themselves under siege at the Lighthouse.

Daisy's future as the Destroyer of Worlds could take a critical change.

While Fitz and Enoch struggle in space, Sarge and his team move forward with their mysterious mission on Earth.

Who will survive? It all comes down to this.

Coulson and the Agents of S.H.I.E.L.D. are thrust backward in time and stranded in 1931 New York City. With the all-new Zephyr set to time-jump at any moment, the team must hurry to find out exactly what happened. If they fail, it would mean disaster for the past, present and future of the world.

With their backs against the wall and Nathaniel and Sibyl edging ever closer to eliminating S.H.I.E.L.D. from the history books, the agents must rely on their strengths to outsmart and outlast the Chronicoms. This is their most important fight, and it will take the help of friends and teammates, past and present, to survive.