While on a mission to learn more about the secrets of the mysterious writing, Coulson finds himself attacked by the only person he can trust: Agent Melinda May. Meanwhile, the rest of the team is trapped in an explosive situation, and it's up to Fitz to save them--but is he up to it?

Coulson and his team come to the aid of a confused Lady Sif, who has lost her memory after fighting with a mysterious warrior whose mission will send shockwaves through S.H.I.E.L.D. Meanwhile, Bobbi and Mack continue to hide their true mission from everyone close to them.

Gonzales and Coulson must find a way to put their differences aside and work together against HYDRA, even if it means teaming up with someone they don't trust.

The stakes get even higher as Hunter and May continue to go after Ward and HYDRA, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.

When a radical group called The Watchdogs emerges with plans to eliminate the Inhumans, Agent Mack and his brother become caught in the crossfire. Meanwhile, Simmons discovers a powerful chemical compound that could alter the future for Inhumans.

S.H.I.E.L.D. takes on Hive, and when his master plan is finally revealed, the team must spring into action.

Daisy goes to battle Ghost Rider at a terrible cost, and Coulson faces the new Director, and his bold agenda surprises them all.

May works to uncover the truth about what happened to her; Aida's next move puts everyone's life at risk.

Coulson and the team discover what their captors' true intentions are, and in space, escape is not an option.

Coulson and the team set out to rewrite the course of humanity's fate; they're unaware that their efforts will dramatically change one S.H.I.E.L.D. agent's life.

Daisy's future as the Destroyer of Worlds could take a critical change.

The party’s over, and now the team must trust each other in order to face impending doom and an enemy that’s closer than they think.

A time storm ravages the Zephyr, propelling it toward destruction while simultaneously forcing Daisy and Coulson to relive their failed attempts to save the team over and over, until they find a solution or are swallowed by the storm. Making it to their next destination will take trust, courage and sacrifice from everyone on board, but it will all come down to having enough time.