When a new Inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.

As Daisy and the team fight to protect Inhumans, S.H.I.E.L.D. discovers the shocking truth about one of their foes; Fitz helps Simmons recover information that could lead them back through the portal.

Ward's campaign for revenge brings the S.H.I.E.L.D. team to their knees, and Coulson proves he will do anything to settle the score.

S.H.I.E.L.D battles HYDRA head-to-head, which sees Coulson and Fitz take the ultimate risk while Daisy and the Inhumans try to keep HYDRA at bay.

In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to HYDRA once and for all. Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D.?

Agent Daisy Johnson must call upon the Secret Warriors for an inaugural mission that will leave no member unscathed, and S.H.I.E.L.D. learns more about Hive's powers, forcing them to question everyone they trust.