Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Phil Coulson and the team can save them before the clock ticks out.

Daisy, Director Mace and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Meanwhile, Coulson and Mack come face-to-face with Radcliffe’s inspiration for Aida.

Mace fights for his life while Coulson and team find themselves in a deadly cat-and-mouse game as they attempt his rescue.

Suspicion turns to paranoia when the team doesn't know who can be trusted as more LMDs infiltrate S.H.I.E.L.D.

Daisy finds herself teamed up with an unlikely partner. Meanwhile, Aida prepares to put her ultimate end game into effect.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.

With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.

As Fitz and Simmons race to find a way to seal the Rift, they are faced with one of their greatest fears manifested.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.