As Coulson, Mack and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide, Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness.

As Robbie Reyes struggles to control the Ghost Rider; S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.

Robbie's shocking story on how he became Ghost Rider is finally discovered as Coulson and his team's lives hang in the balance.

With the loss of half the team, the remaining members search for answers as the clock counts down for Ghost Rider.

S.H.I.E.L.D. and Ghost Rider find themselves unlikely allies when the lives of all of Los Angeles hang in the balance.

Coulson is unaware of a dark secret May is hiding, even as the two grow closer; Aida is determined to find the Darkhold.

Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.

As Daisy and Simmons struggle to discover an escape route to the real world, the identity of the Inhuman leader of the Resistance is revealed.

The truth behind Fitz's turn could bring down all of S.H.I.E.L.D..

Daisy finds herself teamed up with an unlikely partner. Meanwhile, Aida prepares to put her ultimate end game into effect.

The clock is ticking for Daisy and Simmons to get the team out of the Framework, but not everyone is ready and willing to leave.

With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.