As Ghost Rider's quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need; and Daisy reunites with a familiar face to stop the Watchdogs.

Mace fights for his life while Coulson and team find themselves in a deadly cat-and-mouse game as they attempt his rescue.

Just as the team reunites, they become prey to an undefeated Kree warrior bent on killing them all.

As Fitz and Simmons race to find a way to seal the Rift, they are faced with one of their greatest fears manifested.