Coulson and the team set out to rewrite the course of humanity's fate; they're unaware that their efforts will dramatically change one S.H.I.E.L.D. agent's life.

In the milestone 100th episode, Coulson finally reveals the mysterious deal he made with Ghost Rider, which will impact everyone on the team.

The team goes in search of Gravitonium in order to save the world.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

The team must find a way to stop Ruby before the prophesied chain reaction that can destroy the Earth is put into motion.