When a new Inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.

Fitz and the team enlist the aid of an Asgardian to unlock the secrets of the ancient Monolith that swallowed Simmons, and Agent May is at a crossroads in her personal and professional life.

With the surprising help of Lance Hunter, nothing will stop Fitz from finding the lost team as his incredible journey is revealed.