Forced to take on new identities provided by Root, the team members try to adapt to their new lives. However, some find it hard to ignore The Machine's numbers, which puts them all at risk of being detected by Samaritan.

Despite not wanting to help with the new numbers, Finch's interest is piqued when the newest person of interest turns out to be a brilliant college student involved with a mysterious scavenger hunt.

Finch recruits Fusco to stick close to the latest POI, a professional 'wingman', but learning how to approach women soon becomes the least of his worries. Reese must find a way to play by the rules at his new day job. The Machine sends Finch and Root on a mysterious errand.

Reese's cover job as a detective at the NYPD becomes complicated when the young brother and sister he's protecting become targets of a gang investigation.

While Reese is forced to go to counseling for his violent tendencies, Root, Shaw and Finch try to help a new POI.

Reese, Shaw and Fusco must protect a unassuming office worker who stumbles into a dangerous conspiracy while moonlighting as fake detective. Finch travels to Hong Kong as part of his academic cover identity.

Shaw joins a team of international thieves in order to keep tabs on the latest POI, but an unexpected turn of events puts her in danger of being detected by Samaritan. Also, Finch and Root undertake a dangerous sabotage mission.

Reese volunteers as an NYPD police academy instructor in order to keep an eye on a talented young officer whose suspicious actions make him question her motives. Meanwhile, Martine – armed with information from Samaritan – hunts a member of the team.

Reese must save Elias from the Brotherhood. He can't get any help from Root or Shaw since Shaw's cover is blown and Root is escorting her to underground.

Samaritan shows its power by erasing crime from the city for a day in an attempt to force The Machine out of hiding.

Samaritan launches a cyber-attack on the stock exchange, forcing the team to risk their lives in a desperate mission to stop a global economic catastrophe.

Control, who oversees the handling of relevant numbers for the government, begins to question the methods and intentions of the Samaritan program. Also, alarming news reports of a pair of vigilantes rampaging through the Northeast begin to surface.

Root and Reese investigate a small town in upstate New York that holds the key to Shaw's location... and whether she's dead or alive.

When the Machine arranges for Finch to sit on the jury of a murder trial, he begins to suspect that a fellow juror is set to rig the proceedings. Meanwhile, Reese begins to open up to the department’s therapist.

Reese tries to protect a software programmer with a mysterious second life, but it’s unclear which side of her life the threat is coming from. Meanwhile, Claire, a young hacker whom Finch tried to protect from Samaritan, reaches out to him for aid.

Reese and Finch must protect Harper, a street-smart grifter, when her plan to steal cash from a medical marijuana dispensary goes up in smoke.

Reese and Finch try to protect a psychologist whose unorthodox methods for helping his patients find closure could cost him dearly. Meanwhile, flashbacks reveal Finch’s fragile state in the days following the bombing that killed his best friend, Nathan Ingram.

Reese must protect a bounty hunter who refuses to allow the potential threat to her life sway her from the relentless pursuit of her target. Also, Finch tries to set the plan he began in Shanghai in motion.

Reese and Finch scramble to protect a software CEO when his behavior becomes increasingly erratic following a hacker attack that reveals all his secrets and unravels his life.

Reese finds himself on a dangerous personal journey when he takes on a homicide case Detective Carter was never able to close.

Reese and Fusco get caught in the war between the two newest POIs, rival crime bosses Elias and Dominic. Also, a tantalizing clue to Shaw’s whereabouts leads Finch and Root into a possible trap, and Control goes rogue to uncover the true intentions of the Samaritan program.

Finch and Root race to save The Machine, which has been located by the rival AI, Samaritan. Also, Reese is caught in the middle of the final showdown between rival crime bosses Elias and Dominic.

Reese and Finch attempt to rescue the Machine’s source code before it deteriorates beyond repair. Also, Root fights for her life against an onslaught of Samaritan’s agents and Fusco is faced with hard questions following the deaths of Dominic and Elias.

The Machine experiences a glitch during rebooting, supplying Reese and Fusco with the numbers of dozens of people not actually involved in crimes, while also locking Finch and Root out after identifying them as threats based on past violent behavior.

Reese’s cover could be blown when he realizes the latest POI has ties to his old CIA colleague, Kara Stanton.

Shaw escapes her captors, but the team is unsure of her mental state when she begins to act paranoid and reckless.

Reese protects an NYPD analyst whose investigation into a software glitch has drawn the attention of Samaritan. Also, Reese and Fusco are threatened by an ally of Elias’s, who is looking to avenge his friend’s death.

The Machine sends Reese and Finch to a wedding to protect a pair of POIs before their nuptials. Also, Fusco becomes angry at being kept in the dark by the team and takes it upon himself to investigate a string of missing person reports.

Root goes undercover at a radio station to protect the host of a conspiracy theory show who stumbles upon information that could get him killed. Also, Samaritan’s agents try to convince a member of the team that their goals are noble.

Reese and Finch become trapped in a hospital that becomes ground zero for a deadly viral outbreak. Also, Samaritan’s newest recruit has second thoughts and Shaw continues to struggle with reality.

The mysterious criminal mastermind known as “The Voice” returns and traps Reese and Fusco in their own precinct with several armed gang members and the latest POI. Also, Root makes a shocking discovery.

Finch’s number comes up when a fatal error blows his cover identity and sets off a deadly series of escalating encounters with Samaritan’s operatives.

The team must unravel a conspiracy and stay ahead of the Secret Service when the President of the United States becomes their newest POI. Also, Finch separates himself from the team and considers taking drastic action to combat Samaritan.

As Reese and Shaw race to catch up with Finch, he infiltrates a maximum-security government facility in a desperate mission which could mean the end for not only Samaritan, but for himself and The Machine as well.

Finch, Reese, Fusco and Shaw embark on one last mission to prevent Samaritan from destroying The Machine and cementing its hold over mankind.