When the body of a young hooker is found in the district, Dutch's theory about a serial killer preying on prostitutes proves true. Aceveda launches an all-out effort to find the killer before he strikes again, giving Dutch and Claudette the full resources of the Barn for 24 hours and the help of the FBI.

Vic's relationship with Shane becomes even more complicated when the pair team up with a detective from another precinct to investigate the murder of several gang member. Meanwhile, Dutch and Claudette bring in a psychic on a complaint from the son of one of her clients.

As racial tension in the area escalates, the Strike Team attempts to end a race war, while Claudette and Dutch investigate a riot at a high school. Meanwhile, an Internal Affairs officer begins his investigation of Vic and the Strike Team by first zeroing in on Lem. A pregnant Danny refuses to reveal the identity of the father, and Julien begins training a rookie cop named Tina Hanlon.

Kavanaugh seeks the help of Antwon Mitchell in his ongoing quest to take down the Strike Team. In the midst of this, Kavanaugh has a lot on his mind as his ex-wife reenters the picture, and he reluctantly agrees to let Vic send Emolia undercover to infiltrate a Salvadoran gang that is stockpiling grenades.