Politically ambitious new LAPD captain David Aceveda tries to crack corruption in Los Angeles' Farmington District by recruiting detective Terry Crowley to help him take down fellow detective Vic Mackey, leader of the Farmington precinct's Strike Team. As Vic and the Strike Team prepare for a dangerous night mission, detectives Holland "Dutch" Wagenbach and Claudette Wyms investigate a woman's murder, only to discover that her missing daughter has been sold off by the daughter's drug-addicted father to a child molester.

Allegations against the Strike Team are front-page news, and the team is reassigned pending the investigation. Vic and Claudette find themselves following the trail of a deadly meth batch, while Shane and Dutch team up to investigate the unsolved murder of a widow's husband.