Detective Sherlock Holmes, along with his sober companion, Dr. Joan Watson, uses his uncanny ability to read people and analyze crimes to assist the NYPD on some of their more difficult cases. In the season premiere, Holmes consults on a home invasion that resulted in murder.

Sherlock uses his powers of deduction to consult on the murder of a young man who is shot upon entering his apartment. Meanwhile, Watson has dinner with her ex-boyfriend, Ty Morstan.

Sherlock and Watson consult on a child abduction case involving a serial killer who is nicknamed "The Balloon Man," because he leaves a signature batch of balloons at each of his crime scenes.

Sherlock is reunited with “M.” a British criminal who appears to have followed Sherlock to New York. Meanwhile, Joan has reservations about leaving Sherlock and taking on a new client.