When a debt collector is murdered, Holmes and Watson try to narrow down the suspect pool from thousands of consumers who owed the victim money. Meanwhile, Watson’s relationship with Andrew progresses when he asks her to meet his father for the first time.

When Holmes faces criminal charges in the aftermath of his recent violent behavior and relapse, his powerful father arrives in New York to fix his estranged son’s legal difficulties by any means necessary. Also, with Holmes and Watson’s consultancy with the NYPD in jeopardy, Holmes concentrates on the case of a missing wife believed to have been killed by her husband to try and get back in the department’s good graces.

Holmes and Watson investigate multiple motives for murder when a zoologist is killed because of his numerous love affairs or his trailblazing research. Also, Holmes finds himself the victim of identity theft after his medical records are stolen.

Holmes and Watson race to locate a missing woman when Harlan Emple, Holmes’ friend and “Irregulars” mathematics expert, becomes the prime suspect in her disappearance.