Holmes and Watson investigate a mass murder when a chef and his patrons are poisoned after dining on a tasting menu tainted with snake venom. Also, Detective Bell’s crush on a work colleague makes Holmes realize his and Fiona’s relationship is at an important crossroads.

Holmes and Watson get mixed up in murder and magic when they investigate the death of a magician killed while performing a classic stunt. Also, Watson suspects Bell is being targeted by the ex-husband of his girlfriend, Chantal, after a false allegation lands him the middle of an Internal Affairs investigation.

Detective Bell considers leaving the NYPD when he is recommended for a once-in-a-lifetime career opportunity. Also, Holmes and Watson are hired by a private client to investigate the disappearance of a young woman who led a double life online as a financial dominatrix.

Holmes and Watson’s deadly conflict with Sherlock’s former friend Michael intensifies when their newest victim looks to be the serial killer’s latest prey.