A severe car crash involving an entire family results in an all-hands-on situation in the ER, as the eldest daughter is left to make the toughest decision of her life. Meanwhile Teddy, still in the dark about Henry's death, calls upon Cristina to help with her patient in the O.R., and Lexie finds herself working alongside Mark's new girlfriend, Julia, during an eye surgery.

The doctors work on a Jane Doe, who turns out to be the subject of a case that gained national interest; Cristina proves to be the highest in demand as the residents begin their interviews for post-residency positions at prospective hospitals; and Richard is faced with an unsettling realization when he visits Adele at Rose Ridge.

Bailey puts her wedding day on hold and continues her efforts to save Adele's life, Cristina and Owen remain undecided about their pending divorce, while Arizona and Callie try to get their spark back. Meanwhile, the hospital becomes inundated with a group of bikers after a horrible accident.

After an anonymous complaint is issued by one of their own, the hospital implements a non-fraternizing policy causing the couples to panic. Meanwhile, Emma and Owen talk about the future, Cristina and Meredith enjoy a little girl time, and Richard enlists the residents to help research a rare cancer case.

After several discussions with Dr. Herman, April and Jackson must face their situation head on and make a difficult decision regarding their unborn child. Catherine arrives in Seattle and bumps into Richard at the hospital. Meanwhile, Meredith tries to find someone to take care of the kids so she can visit Derek for the weekend, and Amelia shows Stephanie some tough love when they work together on a case