Meredith and Carina question DeLuca’s uncharacteristic behavior when he volunteers to perform a life-threatening task during a blizzard. Meanwhile, Bailey tries to help Joey with his future, while Richard trains a new intern at the hospital.

The hospital ventilator shortage has the doctors gravely concerned when both a mother and daughter are in critical condition with COVID and fighting over the last ventilator. Meanwhile, Hayes’ high-risk sister-in-law with multiple sclerosis ends up in the hospital with a kidney stone, and the sister house has a few more kids join it as Amelia plays babysitter for the day.

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own; Meredith works to save Dr. Hamilton's life. Levi is impacted from his latest loss.

Tensions at Grey Sloan Memorial rise as the effects of the physician shortage begin to show. Meanwhile, Meredith struggles to step away from work as she spends a sick day at home with Zola, and the hospital receives an unexpected visitor.

Catherine returns to Grey Sloan for a surgical case that makes Lucas and Blue queasy. Amelia treats a possible cancer patient with a family that’s a little too supportive. Owen takes his medical future into his own hands, much to Teddy’s surprise.

With Levi’s help, a patient celebrates a milestone. Jo processes a difficult diagnosis, and Maggie and Winston decide their future.

The aftermath of the convenience store shooting brings chaos to Grey Sloan. Ben hits a wall with his new emergency preparedness plan. Romantic tensions surface for Owen, while Amelia and Winston disagree over the surgical plan for a young patient.