Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient's family. Jo and Link struggle with wedding planning.

Jo and Link's wedding day arrives, along with some visitors. Meanwhile, Teddy and Owen are met with a familiar face seeking treatment, and Lucas disagrees with Simone on how to approach a patient's worsened condition.

While the interns are excited to transition to second-year residency, an ordinary day at Grey Sloan takes an unexpected turn when a medical emergency unfolds in the operating room, endangering lives inside the hospital.