Grissom and Sara investigate a bug riddled body found in the desert. Warrick and Catherine look in to the theft of some valuable art. Nick gets to find out why a missing woman's car is found at the bus station. Warrick is suspected of having gambled on duty.

A woman is abducted from a supermarket. In the store, Grissom finds a bathroom stall door that claims five women have been killed. Warrick is caught in a casino on duty and is paired with a reluctant Sara. Their case is the apparent murder and robbery of a man who is found be his brother. Nick gets pulled in by his prostitute friend who gets in a scuffle with hotel security.

A man convicted of arson and the murder of his wife and child seeks assistance from Grissom to help prove his innocence. Meanwhile, Catherine and Nick investigate the underground world of sports gambling when a teenager is murdered at close range.

Grissom and Willows return to help the CSI team solve a catastrophic case that paralyzes all of Las Vegas.