Eight-year-old Brian (who is 56 in dog years) seems to have lost a step or two, so Peter gets a new talking dog, New Brian, to "take some of the load off" the old one, who doesn't like the idea at all.

Peter imagines his friends and family in three of Stephen King's most famous works. Stand by Me parody - Twelve-year old Peter, Quagmire, Cleveland and Joe travel along a railroad track on a journey of self-discovery. Misery parody - Brian is injured in a bad car crash only to be "rescued" by his "number one fan," Stewie. The Shawshank Redemption parody - Cleveland and Peter become fast friends in prison.

When Peter hits his head and suffers amnesia after getting in a fight with Richard Dawson on Family Feud, he forgets everything about his life, including his family and friends. In an attempt to try to bring back his memory, Lois decides to reintroduce Peter to his old self, until he begins to hit on other women, much to Lois's dismay. She decides to take the kids and leave Peter, giving Quagmire the opportunity to score with Lois. Peter now must prove to Lois he can remember her and make himself worthy of her again.

In the 150th episode, Brian & Stewie get locked in a bank vault, they are forced to deal with each other on a whole new level.

Unlike any other FAMILY GUY episode, the acts will play out in real time as Brian and Stewie react to being locked in a small space with no baby food or martinis to keep them from losing their minds while they hatch an escape plan.

Lois is outraged when local news anchor Joyce Kinney airs a negative profile on her.

When Quagmire recovers from his "accident" he learns that his sister Brenda needs his help.

Brian and Stewie travel back in time to the pilot episode of FAMILY GUY to change history, and then to change history again.

On Valentine's Day, Meg goes on a date with a guy she met online, and Lois and Peter stay in bed all day; Brian is visited by his ex-girlfriends.

Tired of not winning an Emmy, Peter embarks on his own For Your Consideration campaign for Family Guy by making the show more like Emmy-winning shows - and no category is off limits.

When Peter makes it through a bad flu season without getting sick, the hospital asks him to volunteer as a nurse, but he finds himself at a crossroads when his mortal enemy, The Giant Chicken, is admitted to the ER. Meanwhile, Brian receives his genetic test results and learns he is part cat, causing him to have an identity crisis.