Meg is enlisted to check in on Susie and Joe while Bonnie is away but she soon becomes a little too involved. Meanwhile, Stewie accidentally creates an evil twin.

After running into Jesus at the Quahog Mall, Peter is stunned to discover that the Son of God is still a virgin. So, he enlists Quagmire and Cleveland to help him throw Jesus the best birthday ever by finding a way to help him become a man.

Peter’s sister, Karen, decides to come for Thanksgiving and bullies Peter the same way Meg treats him. While Meg is at first amused, she later feels badly and decides to help Peter train to defeat his sister in a wrestling match. Meanwhile, to avoid overeating on Thanksgiving, Stewie and Brian decide to go on a cleanse, which Stewie takes one step too far.

Peter helps Joe out with several crime cases, but when Joe tries to take all the credit, Peter gets extremely angry. Meanwhile, Brian convinces Stewie to join a football team and panics when he gets a concussion.

Chris receives a special one-dollar bill as a birthday present, but he quickly loses it and the dollar passes into the possession of everybody in Quahog.

To help get Brian's life in order, Stewie and Brian swap bodies using a machine that Stewie invents, but chaos quickly ensues around Quahog when the machine goes haywire.

When Stewie receives a participation medal in his school's toddler games, he begins to question everything he has ever won. Meanwhile, Peter causes a fight between Lois' parents and must repair the damage he caused.

When Meg takes Stewie to the mall to meet Santa, she has a surprising response. Meanwhile, Stewie is entirely scarred from the same experience and Brian tries to help him process it.

Peter's non-stop sweating becomes a liability at his company, so his boss tells him to work from home. Meanwhile, after Stewie and Chris cause thousands of dollars in damage to an electronics store, the two create a fake Kickstarter campaign with Brian to pay back the money.

With a newfound love for rocking out to Van Halen, Peter gets in a car accident and falls into a coma.

Cooped up in a hotel room due to a big storm, the Griffins pass the time by reimagining three stories from the Bible.

Peter and Lois accidentally set up a cutaway gag together, which somehow transports them into the cutaway itself.

When Joe asks Peter to be the godfather to his daughter, Peter commits to his mistaken interpretation of the role so much that he becomes a real gangster.

Brian's new job as a journalist leads him to uncover that Pawtucket Pat, Quahog's hero and brewery founder, took part in racist actions against Native Americans. The town becomes divided on whether or not to remove the statue that commemorates him.