Lois and Peter are divided by differing views on who the next Mayor of Quahog should be. Upset at Lois' first choice, Peter seeks out the late Mayor Adam West's cousin, Wild Wild West.

When Peter makes it through a bad flu season without getting sick, the hospital asks him to volunteer as a nurse, but he finds himself at a crossroads when his mortal enemy, The Giant Chicken, is admitted to the ER. Meanwhile, Brian receives his genetic test results and learns he is part cat, causing him to have an identity crisis.