'You cannot lose if you do not play.' - Marla Daniels.

McNulty feels the heat when a witness who testified against D'Angelo is found murdered. Meanwhile, Greggs is given the lay of the land regarding Avon Barksdale's key players, and Herc, Carver and Prez find big-time trouble at the towers.

"..and all the pieces matter." - Freamon.

When Rawls looks to make a premature arrest for three murders that are linked to D'Angelo and Avon Barksdale, McNulty and Greggs must argue for a delay in order to preserve the valuable wiretap gains they have made. Meanwhile, Wallace and D'Angelo struggle with their consciences after Avon pays them blood money.

'They can chew you up, but they gotta spit you out.' -- McNulty

Major Valchek gets back at Sobotka for the church gift fiasco, and a feud begins. Valchek ups the ante by asking Deputy Commissioner Burrell for a detail to go after Sobotka. Avon Barksdale continues to run his empire from a prison cell--counseling his nephew D'Angelo and going after a guard who is harassing the organization's convicted hit-man Wee-Bey.

'It don't matter that some fool say he different...' -- D'Angelo

Trying to let go of police work and return to his marriage, McNulty gives up on identifying his Jane Doe. In their investigation of Sobotka, the detectives discover a pattern in the computer and explain the connection to Daniels, but he still won't take the murders. Sobotka tries to play the political game on behalf of his union.

"There's never been a paper bag." -- Colvin

Omar continues his bold strikes on Barksdale stash houses, now heavily guarded. Under orders from Stringer Bell, Bodie faces a critical test against Marlo, a fierce young dealer with lucrative corners. As the wire on Proposition Joe continues to yield little, McNulty launches his own reinvestigation of last year's prison suicide of D'Angelo Barksdale.