4400 people, assumed to be dead or missing over the past fifty years, reappear in a ball of light. None have any memory of where they've been, and some are manifesting paranormal abilities.

Diana helps Tom break Kyle out of NTAC quarantine, eventually leading them to discover the truth behind the 4400.

Tom and Diana investigate a 4400 whose ability to increase the human bodies' metabolism just may be this weight-conscious world's answer to the ultimate fat-burner.