A deadly virus outbreak on a college campus sends Echo back to school where pieces of her past come into focus.

After her entanglements with Senator Perrin and the DC Dollhouse, Echo finds herself out in the world-at-large as she struggles to control her multiple memory downloads. Topher discovers the dangers of science that will have devastating effects on the future, while Adelle engages in a power struggle with Harding.

Topher races to reconstruct Echo's original personality and memories when Adelle realizes they are the key to averting a devastating future. Meanwhile, Echo and Bennett's shared past and the identity of The Rossum Corporation's mysterious leader are revealed.