Starsky and Hutch blow a Federal stake-out in order to intervene and stop violent rapist Jojo Forentic from committing his latest attack. But after they apprehend the attacker, who sprays his victims with orange paint, the duo find themselves struggling in an up-hill battle trying to get Forentic put away.

The intrepid cops go undercover at a mental hospital, with Starsky as a patient and Hutch as an orderly, to investigate a number of mysterious patient deaths that have occurred at the asylum. With a female journalist, also undercover as a patient, they uncover that someone in the hospital is illegally using patients as human guinea-pigs for the testing of behaviour modification drugs...

Starsky and Hutch brush shoulders with high-society, at an exclusive party that photographer friend Marcie has invited them to, but the event grinds to a halt when an artist is shot dead by an unknown assassin. Marcie has caught the shooting on camera, and the Detective duo confiscate the pictures for Police evidence as they begin some black-tie sleuthing on the champagne circuit. But Marcie is determined to use the valuable photos to break into big-time journalism, and quietly holds on to one to sell to the highest bidder – only for her life to now be endangered by the killer, who is determined to get their hands on the incriminating film...