It's the first day of school at Acme Looniversity. Babs and Buster Bunny meet their new friends, Sweetie Bird, Hamton J. Pig, and Plucky Duck.

Buster and Sweetie join the Tooney Ball team during Electives Week while Babs and Plucky tackle the basics in Anvils 101, leaving Hamton on a journey to fix his indecisiveness.

Hamton gets into medical school but soon realizes it's not at all what he imagined. Buster desperately tries to find a way to bring his pal back to Acme Loo.