After Megamind causes an accident that makes Mr. Donut lose his memory, he convinces himself that the loveable shop owner is on the verge of turning evil and vows to stop him before he becomes a supervillain.

Megamind's confidence is tested when Machiavillain finally reveals himself to the blue hero and puts him through a series of challenges to save the city from destruction.

Megamind faces the ultimate challenge when he must square off against a mind-controlled Roxanne.