When Megamind's body-switching tech causes him and Roxanne to swap bodies, they must figure out how to act as the other before unleashing too much chaos and destruction on the city.

Chum clones himself to get everything accomplished and take care of an ill Megamind; when the clone makes additional copies of himself, things get out of hand.

In an effort to keep his finger on the pulse of Metro City, Megamind goes undercover as an ordinary sales clerk but soon learns there have been a series of robberies and disappearances in the store.

Megamind, Chum and the rest of the team attempt to infiltrate a festival thrown by Machiavillain to expose him as a villain to the rest of the city.