While Artie and Claudia meet with Vanessa Calder and Hugo Miller to investigate a computer virus that transforms people into clay, Myka and Pete wake up naked in bed and try to find a missing Steve.

Pete, Claudia, and Myka are called in to help Fargo, who is trapped in a virtual reality swords & sorcery game. Meanwhile, Artie and Steve are summoned to New York to recover an artifact... by FBI agent Sally Stukowski.

Sally Stukowski and her partner make their move, attacking the Regents and using an artifact to trap them in a building and bring it down around them.

While Pete and his mother Jane try to determine the origins of their mysterious opponents, Myka and Claudia travel to Portland to stop a girl who can apparently vaporize anyone she hates with blasts of radiation.

Myka and Pete deal with a plague of zombies in Ithaca, while Claudia deals with a new romance, a prophecy of death, and a rejection from a friend.

As Sykes begins his end game, the agents discover that Helena is still alive... and teaching high school literature. Meanwhile, Jane reveals the full extent of her plan but one agent will lose their life carrying it out.

Pete and Myka race to stop Sykes from using his own cache of artifacts to destroy them and the Warehouse.

The agents track down a cache of artifacts stolen from Warehouse 12 by the infamous Roaring Dan Seavey... and guarded by his ghost. Meanwhile, Charlotte Dupres makes her move with the help of her inside person.